This species is characterized by its subsessile, medium-sized, lance-elliptic leaves with cordulate bases, terminal inflorescences with 1 or usually 2-3 fasciculate flowers, well developed lobed calyx limbs, well developed white corollas with acute lobes, and well developed ellipsoid fruits. The leaf bases clasp the stems. The flowers are subsessile to pedunclate. This species appears to be rather locally endemic to a region of Central America that does not seem well defined ecologically biogeographically, but some other Rubiaceae species have a similar range (e.g., Psychotria lamarinensis C.W. Ham.).

Faramea zamorana is similar to Faramea correae and Faramea permagnifolia, both of southern Central America. Faramea zamorana is also remarkably similar to Rudgea haemispherica Dwyer ex C.M. Taylor of central Panama; the Rudgea species have truncate to rounded stipules with glandular appendages. This name was originally published with the incorrect form "zamorensis, which is a geographic epithet that refers to a locality called "Zamora", but it was stated to be named for Prof. Nelson Zamora of CR so it correctly takes the personal form "zamorana".