This species is characterized by its elliptic, leathery, shiny leaves with the margin thickened and secondary veins not visible, short triangular stipules with developed aristas, and terminal cymose inflorescences with pedicelllate flowers, short truncate calyx limbs, tubular white corollas with tubes ca. 5 mm long and lobes ca. 3 mm long, and oblate fruits 4-5 x 8 mm. The leaves are unusually thick-textured. The venation is weakly evident on some dried specimens, and has secondary veins that extend to unite with the margins. The inflorescences are characteristically subtended by foliaceous bracts or, alternatively, the inflorescences are sessile; this arrangement was called "sessile and tripartite" by Standley. Specimens of Faramea juruana characteristically dry yellowed. This species is commonly collected in many areas.

Faramea crassifolia is similar to Faramea boomii, with clearly marked secondary leaf veins that extend directly to unite with the margins and larger flowers. Faramea crassifolia is also similar to Faramea juruana, with larger leaves with some of the venation visible annd larger flowers and fruits. Faramea crassifolia is also similar to Faramea nitida, with secondary leaf veins that loop to form a submarginal vein.