This species is characterized by a lianescent habit, rather stout main stems bearing shorter lateral branches, medium-sized leaves with distinctive venation, rather stout peduncles with several to numerous flowers in a congested dichasial cymes, well developed narrowly triangular calyx lobes, corollas 30-35 mm with shortly obtuse lobes with rounded marginal wings, and medium-sized ellipsoid-oblong fruits. The leaves have the tertiary venation reticulated into an "intersecondary" vein and densely lineolate quaternaary veins.The hypanthium varies from glabrescent to densely strigillose. The corollas are pale green on the tube and outsides (abaxial surface) of the lobes and whilte to yellow on the internal (adaxial) surfaces of the lobes. The fruits are described as purple-black.

The taxonomy of this species here differs from the usage of some other authors, but does follow Steyermark (1972). He separated Chomelia  glabriuscula from Chomelia grandifolia, and did not contrast these with Chomelia malaneoides but separately recognized that also. All three are similar and have been confused (e.g., Taylor et al. 2004). Here, Chomelia malaneoides is characterized by flowers borne in subcapitate groups of 3-7, with  these groups closely set at the top of the peduncle; also the calyx lobes are well developed and narrowly triangular. Chomelia glabriuscula was separated by Steyermark based two specimens from French Guiana narrowly triangular calyx lobes and the calyx limb and hypanthium sparsely strigillose. This pubescence pattern characterizes a few of the specimens seen from French Guiana and northeastern Brazil, and is not completely distinct because a continuum is seen from this condition to other specimens that are moderately to densely strigose-strigllose in similar specimens from this region. All of these latter are here included in Chomelia glabriuscula, which is characterized by cymose inflorescences with the flowers arranged in dichasia. The flowers are sometimes closely set with some subcapitate groups of 2-3, but some axes are developed.

Chomelia glabriuscula is also similar to Chomelia grandifolia from northeastern Brazil. Steyermark separated it by its shorter and more broadly triangular calyx lobes; additionally, these are markedly unequal on flowers of several of the specimens seen. In inflorescence arrangement Chomelia grandifolia is generally intermediate between Chomelia malaneoides and Chomelia glabriuscula, and further study may show that it is not separable from Chomelia malaneoides. However, as noted by Steyermark, the calyx lobe form distinguishes it from Chomelia glabriuscula, and the corollas of Chomelia grandifolia are described on labels as white and apparently may be shorter.