This species is characterized by its rather small elliptic leaves, short petioles, tubular stipules 3-10 mm long that are fused into tube, solitary, terminal, subsessile flowers enclosed by two foliaceous ovate bracts, very short lobed calyx limbs, blue corollas with tubes 8-15 mm log and lobes 10--12 mm long, and subglobose to oblate fruits 5-7 x 8-10 mm. The leaves have weakly developed looping submarginal veins. The stems often have a distinctive verrucose surface, but this character varies in this and some other Faramea species. The stipule usually dehiscence at their base and then often remain attached to the stem, encircling it.

The leaves, flowers, and fruits of Faramea uniflora vary rather markedly in size, and the fruits vary from smaller and subglobose to a little larger and laterally flattened. Plants wiht larger leaves usually have fewer pairs of them along a stem and larger corollas and fruits. These larger-leaved plants are found in various localities without apparent pattern. More study may clarify the dynamics of this species or species complex. The type of Faramea uniflora has relatively large leaves and flowers and smooth stems, but stipules similar to those of most plants of this species. Some other specimens from the same general region have well developed stipules, to 25 mm long, that open by a slit along one side but no other apparently differences. More study may clarify the dynamics of this species, or species complex, but probably will have to include field study.

Faramea uniflora is similar to Faramea angusta, with few-flowered axillary inflorescences and larger fruits. The smaller-leaved plants of Faramea uniflora are similar to Faramea cupheoides, with obtuse leaves. Faramea uniflora is also similar to Faramea quinqueflora, with the flowers pedicellate and several in a pedunculate fascicle.