This species is characterized by its tree habit, strigillose to strigose pubescence on stems, petioles, and leave undersides, medium-sized (for Simira), petiolate, elliptic leaves with acute to shorly rounded bases, pyramidal several-flowered inflorescences, 4-5-merous flowers, funnelform corollas with the tube ca. 4 mm long and the lobes ca. 3 mm long, subglobose woody capsules 3.5-5 cm in diameter. The specimens characteristically dry with a yellowish brown or greenish brown color. The leaf blades have well developed tufted domatia. The calyx limb is 2.5--3 mm long with trianguar, obtuse to acute lobes. The corolla is described on labels as creamy whit.

Simira lezamae is similar to Simira hirsuta of northern Colombia, with hirsute and leaves without domatia. Simira lezame is also generally similar to Simira cesariana of northern Colombia, and Simira pikkia of Brazil and Bolivia.