This species is characterized by medium-sized leaves, tertiary and quaternary venation that is not visible or loosely reticulated, slender peduncles, flowers pedicellate in lax cymes, yellow corollas 8-10 mm long, and mediums-sized purple fruits. The stems often produce short-shoots, but usually at the ends of a series of expanded internodes. The plants are described as spiny on some labels and by Lorence et al. (2012), but almost no spines are present on the flowering stems collected for harbarium specimens.

Chomelia microloba is similar to Stenostomum acreanum, and has been confused with that species. The application of this name here follows Lorence et al., and differs from that of Burger & Taylor (1993) as outlined by Lorence et al. (2012: 54). Chomelia microloba has a rather distinctive appearance in fruit, and no differences are evident between this and Chomelia laxiflora and these are synonymized here.